Wellbutrin to lose weight | OffshoreCheapMeds Wellbutrin to lose weight is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and to help people quit smoking (smoking cessation). It's already known that people lose weight soon after starting Wellbutrin treatment. A study in 2016 found that people who took bupropion lost around 7 pounds more than those who took other antidepressants over 2 years. Go to: https://www.offshorecheapmeds.com/blog/wellbutrin-to-lose-weight/