The effectiveness of Zhewitra 60 mg, which contains vardenafil hydrochloride, can vary among individuals and depends on several factors, including dosage, individual response, underlying health conditions, and adherence to usage instructions. While there is no specific time frame when Zhewitra 60 mg becomes ineffective, there are several factors to consider:

1. Tolerance: With continued use of Zhewitra 60 mg or any medication containing vardenafil, some individuals may develop a tolerance to the drug over time. This means that they may require a higher dose to achieve the same level of effectiveness. If individuals find that Zhewitra 60 mg is no longer as effective as it once was, they should consult their healthcare provider to discuss possible dosage adjustments or alternative treatment options.

2. Underlying Health Conditions: The effectiveness of Zhewitra 60 mg may be affected by underlying health conditions such as diabetes, cardiovascular disease, hypertension, or neurological disorders. These conditions can impact blood flow and nerve function, which are essential for achieving and maintaining an erection. Managing underlying health conditions effectively may help improve the effectiveness of Zhewitra 60 mg.

3. Medication Interactions: Zhewitra 60 mg can interact with certain medications, including nitrates used to treat chest pain (angina) and alpha-blockers used to treat high blood pressure and prostate conditions. Concurrent use of these medications can lead to a dangerous drop in blood pressure and may reduce the effectiveness of Zhewitra 60 mg. Individuals should inform their healthcare provider about all medications they are taking to avoid potential interactions.

4. Psychological Factors: Psychological factors such as stress, anxiety, depression, and relationship issues can also impact the effectiveness of Zhewitra 60 mg. Addressing these psychological factors through counseling, therapy, or lifestyle changes may help improve the effectiveness of the medication.

5. Adherence to Usage Instructions: It's essential to follow the usage instructions provided by a healthcare professional when taking Zhewitra 60 mg. Taking the medication as directed, including the recommended dosage and timing, can maximize its effectiveness.

If individuals find that Zhewitra 60 mg is no longer effective or if they have concerns about its effectiveness, they should consult their healthcare provider. A healthcare provider can evaluate the individual's health status, adjust the treatment plan if necessary, and explore alternative treatment options for erectile dysfunction.