Super Zhewitra, which contains a combination of vardenafil and dapoxetine, is used to treat both erectile dysfunction and premature ejaculation. Grapefruit juice can affect the metabolism of various medications due to its impact on liver enzymes, particularly CYP3A4. This can lead to higher levels of the drug in the bloodstream and potentially increase the risk of side effects. For medications containing Super Zhewitra, grapefruit juice is generally advised against because it can increase the concentration of the drug in your system. As for dapoxetine, while there is less direct information about grapefruit juice specifically affecting it, the interaction with vardenafil is a concern. It's always a good idea to consult with your healthcare provider or pharmacist about potential interactions and to follow their guidance on dietary restrictions when taking medications.