Yes, it is pretty safe, but with precautions so you don't make it worse. Since human hair wigs are real human hair, they should respond to flat irons, curling irons, and blow driers as we do, though our hair grows back, of course.
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Using heat on wigs human hair in a safe manner is about spray application before styling. This somehow protects the hair from heat, therefore diminishing any damage that results from appliance heating. The heat is to be set at low or medium for a fine and delicate wig. If set high, it may cause irreversible damage, which may result in dryness, frizz, and breakage.
Avoid regularly using heat appliances. It is likely to cause dryness on the wig despite your care if you have it styled often with heat appliances. A combination of heat styling and heat-free styles will help in preserving the moisture and textures.
Although washing and conditioning are the essentials, post-styling care comes next in line. Sulfate-free, hydrating shampoos and conditioners for human hair wigs are essential to keep them hydrated and silky. Deep conditioning treatment maintains the quality of the hair over time.
While it is safe to use heat tools on human hair wigs, caution and proper care are necessary to prevent damage and maintain the wig's look and feel for as long as possible.