Sure thing, when I was building, I found out that placement of return vents and using insulated ducts makes a huge difference. Also, choosing quieter air handlers helps. My builder had me look into specs listed on https://tamcoair.com/service/hvac-for-new-construction/, which include information about low-noise units. That convinced me to pay a bit more for silence in the bedroom areas, totally worth it.

Is there a way to reduce HVAC noise in a new house during installation?