Breast cancer is theslotxomost common cancer and the number one cause of death among Thai women and women worldwide. Interesting is Breast cancer patients in Thailand are often younger than patients in the West. The highest average age is 49-51 years, which is different from the Western countries which are often found in women over 60. It is also more likely to be found in young or pre-menopausal patients. Any Young breast cancer patients tend to have a more advanced type of cancer and have a worse prognosis than breast cancer in older women. There are clearly different causes, pathogenesis, and genetic traits.
The treatment of this group of breast cancer patients is most effective. Need to rely on new diagnostic and therapeutic approaches Despite the past, breast cancer is one of the cancers that have developed a relatively good treatment. But there are still a handful of patients who are unresponsive to treatment. Causing the cancer to spread back It was repeated and spread until death.
Professor Dr. Pornchai Ochareonrat, Head of Breast Center Med Park Hospital And a breast cancer surgeon Chaopraya Hospital Surgical specialist and innovative research In the treatment of breast cancer And graduated from world-class medical institutions including Royal Marsden Hospital, Institute of Cancer Research, London, England and Memorial Sloan-Kettering Cancer Center, New York, USA. Discussed the latest treatment for breast cancer patients. Especially in young or pre-menopausal groups in Thailand that it is necessary to use the so-called approach. "Precision medicine)
New innovation "Breast cancer" with precision medicine (Precision Medicine)
Using "precision medicine" science in the treatment of breast cancer. It is an innovative treatment focused on the detection of biomarkers of cancer. It searches for patterns of gene mutations that are important for cancer growth and spread. Leading to the best and most appropriate treatment plan for the specific patient Consists of a holistic approach to treatment Including surgery, radiotherapy and chemotherapy And the use of effective anticancer drugs in cancer control.
New research results Done in premenopausal breast cancer patients with recurrent cancer By relying on knowledge “Precision Medicine” has developed a drug aimed at inhibiting the CDK4 / 6 gene, a gene that controls the division of cancer cells. When administered with CDK4 / 6 inhibitors, it can slow the progression of the disease for up to 2 years, have few side effects, and lead to a longer life with an improved quality of life. Does not respond to medication Testing for other genes such as PIK3CA, the primary gene that controls the progression of breast cancer. Leading to the invention of anti-PI3K drugs
The application of "precision medicine" for the treatment of breast cancer requires advances in genetics technology. Makes molecular studies possible At a lower price The patient's cancer genetic database has been created to increase the effectiveness of treatment. Slow down the recurrence of the disease And reduce the side effects of receiving no useful anticancer drugs in the patients. And gene expression is Result analysis This requires careful interpretation because genetic diversity is complex. The good news is that high-tech genetic abnormalities can now be tested at the Faculty of Medicine at major universities. Or at leading private hospitals in Thailand