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Megalis 10 mg is typically taken orally. The usual dose for treating ED is one tablet taken about 30 minutes before sexual activity. For BPH, the dosage may be different, and it’s important to follow your healthcare provider's instructions. Tadalafil works by relaxing the blood vessels in the penis, which increases blood flow and helps achieve and maintain an erection when sexually stimulated. It also helps to relieve symptoms of BPH by relaxing the muscles in the prostate and bladder.