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1. Nitrates: Sildigra XL Plus 150 Mg should not be used concurrently with nitrates, such as nitroglycerin, isosorbide dinitrate, or isosorbide mononitrate. Combining sildenafil with nitrates can lead to a severe drop in blood pressure, which can be life-threatening.

2. Riociguat: Sildigra XL Plus 150mg is contraindicated in individuals taking riociguat, a medication used to treat pulmonary arterial hypertension. Concomitant use of sildenafil with riociguat can also lead to a significant drop in blood pressure.

3. Alpha-Blockers: Sildigra XL Plus 150 Mg should be used with caution in individuals taking alpha-blockers for the treatment of high blood pressure or prostate enlargement. Combining sildenafil with alpha-blockers can also cause a drop in blood pressure, leading to dizziness, fainting, or other complications.

4. Severe Liver Impairment: Sildigra XL Plus 150 Mg is contraindicated in individuals with severe liver impairment (Child-Pugh Class C). Sildenafil metabolism may be impaired in individuals with severe liver dysfunction, leading to increased levels of the medication in the body and an increased risk of side effects.

5. Severe Kidney Impairment: Sildigra XL Plus 150 Mg should be used with caution in individuals with severe kidney impairment (creatinine clearance less than 30 mL/min). Reduced kidney function can affect the elimination of sildenafil from the body, leading to increased levels of the medication and an increased risk of side effects.

6. Hypersensitivity: Sildigra XL Plus 150 Mg should not be used in individuals with a known hypersensitivity or allergy to sildenafil or any other ingredients in the medication.

It's essential to consult with a healthcare professional before using Sildigra XL Plus 150 Mg, especially if you have any underlying health conditions or are taking other medications. They can assess your medical history and provide personalized recommendations regarding the safety and suitability of Sildigra XL Plus 150 Mg for you.