Vidalista 10 mg, which contains tadalafil, can still be effective after a night of drinking alcohol, but there are several factors to consider:

1. Moderate Alcohol Consumption: If you have consumed a small to moderate amount of alcohol, Vidalista 10 mg may still be effective for treating erectile dysfunction (ED). Tadalafil works by increasing blood flow to the penis, and moderate alcohol intake is less likely to significantly interfere with this process.

2. Excessive Alcohol: If you've consumed a large amount of alcohol, it could reduce the effectiveness of Vidalista 10mg. Alcohol is a depressant and can impair sexual performance by affecting the nervous system and reducing blood flow. In this case, you may find it harder to achieve or maintain an erection, even with the help of the medication.

3. Side Effects: Both alcohol and tadalafil can lower blood pressure. When combined, they may increase the risk of side effects such as dizziness, lightheadedness, or fainting, particularly when standing up. This is more likely if alcohol is consumed in excess.

4. Timing: If you plan to drink alcohol, it's a good idea to do so in moderation and allow some time between drinking and taking Vidalista. This can help minimize the potential for negative interactions.

While Vidalista 10 mg can be effective even after drinking alcohol in moderation, it is best to avoid excessive drinking to ensure optimal performance of the medication and to reduce the risk of side effects. If you have any concerns, it's always a good idea to consult with your healthcare provider for personalized advice.