Malegra 25 mg is a brand name for sildenafil, which is commonly used to treat erectile dysfunction (ED). It works by relaxing the blood vessels in the genital area, increasing blood flow to the penis, which helps achieve and maintain an erection. Malegra 25 mg doesn't directly affect the muscles in the genital area, but it influences the smooth muscle tissue. Sildenafil inhibits an enzyme called phosphodiesterase type 5 (PDE5).

This enzyme normally breaks down a substance called cyclic GMP (cGMP), which helps relax smooth muscle tissues. When PDE5 is inhibited, cGMP levels rise, leading to relaxation of the smooth muscles in the blood vessels of the penis. This relaxation of the smooth muscle allows for increased blood flow into the penis, which results in an erection. Essentially, Malegra enhances the body's natural response to sexual arousal. While Malegra does not directly affect skeletal muscles, it impacts the smooth muscle in the genital area, which is crucial for the process of achieving an erection. It's important to remember that the drug only works when there is sexual stimulation, as the process is reliant on the body’s natural response to arousal.