Malegra contains sildenafil citrate, a PDE5 inhibitor used to treat erectile dysfunction. One rare but serious side effect of sildenafil is priapism, which is a prolonged and often painful erection lasting more than 4 hours. While the risk of priapism with Malegra is low, it increases if the drug is misused—such as taking higher-than-prescribed doses or using it with recreational drugs or nitrates. Men with blood disorders like sickle cell anemia, leukemia, or multiple myeloma are at higher risk. If priapism occurs, immediate medical attention is crucial to prevent permanent penile damage or erectile dysfunction. Always follow dosage instructions carefully to reduce risk.