Tadalista 60 contains tadalafil, which is a phosphodiesterase type 5 (PDE5) inhibitor commonly used to treat erectile dysfunction. The half-life of tadalafil—the time it takes for half of the drug to be eliminated from the body—is approximately 17.5 hours. This is significantly longer than other ED medications such as sildenafil, which typically has a half-life of 4–5 hours. Because of this longer half-life, Tadalista 60 mg can remain effective for up to 36 hours after a single dose, giving it the nickname “the weekend pill.” The extended half-life allows for greater spontaneity, as sexual activity does not need to be precisely timed. However, factors such as age, liver or kidney function, and other medications can influence how quickly tadalafil is metabolized, potentially altering its effective duration. It’s important to follow dosing guidelines to avoid potential side effects.