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- Last updated December 8, 2023
- 0 comments, 1 view, 1 like, 0 followers, 1 member
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- Posted By: Thomas Schmitt
- Posted: Dec 08, 2023
- Last Updated: Dec 08, 2023
- Members: 1
- Views: 1
- Likes: 1
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Overview
Microglia Markers Antibodies
Microglia are cells of mesodermal/mesenchymal origin that migrate into the CNS to become resident macrophages within the unique brain microenvironment. Microglia are highly dynamic cells that interact with neurons and nonneuronal cells.
Microglia express a wide array of receptors and thus respond to pleiotropic stimuli ranging from neurotransmitters to cytokines and plasma proteins. They play a crucial role in the healthy brain as regulators of synaptic functions and phagocytosis of newborn neurons, with important implications in synaptic plasticity and adult neurogenesis. In disease, they play a crucial role in neurodegenerative and neuroinflammatory conditions. Their interactions with T cells are a major component of the development of brain autoimmunity, while their pathogenic interactions with neurons via induction of ROS and iNOS play a crucial role in neurodegeneration.
