Oxycodone is a semi-synthetic opioid analgesic medication sold under various brand names, such as Oxycontin and Roxicodone.... moreOxycodone is a semi-synthetic opioid analgesic medication sold under various brand names, such as Oxycontin and Roxicodone. It helps to relieve severe pain that cannot be aided by over-the-counter analgesics. So, what is the difference between oxycodone and oxycontin? To put it simply, Oxycontin has oxycodone, which acts longer than usual.