Ruxolitinib Phosphate (Ruxolitinib) has become a cornerstone treatment for myelofibrosis, a rare bone marrow cancer. By... moreRuxolitinib Phosphate (Ruxolitinib) has become a cornerstone treatment for myelofibrosis, a rare bone marrow cancer. By inhibiting a specific protein pathway (JAK-STAT), Ruxolitinib helps control symptoms like fatigue, splenomegaly (enlarged spleen), and bone pain, improving patients' quality of life. However, a significant challenge emerges over time: patients develop resistance to Ruxolitinib, rendering the treatment ineffective.