Opioid Receptor Binding: Tramadol binds to opioid receptors in the brain and spinal cord, specifically the mu-opioid... moreOpioid Receptor Binding: Tramadol binds to opioid receptors in the brain and spinal cord, specifically the mu-opioid receptors. These receptors are involved in the perception of pain and the regulation of pain signals.
Inhibition of Norepinephrine and Serotonin Reuptake: Tramadol also inhibits the reuptake of the neurotransmitters norepinephrine and serotonin in the brain. This action increases the levels of these neurotransmitters, which can contribute to pain relief and a sense of well-being.
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