Adverse effects were reported in 20/24 (83%) reviews comparing cannabis and active drugs, and only 6/20 (30%) reported narrative or limited combinations. Many reviews that reported supplementary data did not specify whether side effects could be attributed to placebo or an active drug analogy.

In the medium to high

Quality review, the two pain reviews did not find significant statistically significant differences in cannabis Gummies with codeine or amitriptyline withdrawal due to adverse events [65, 90]. Results from a single cancer review were mixed, with fewer adverse events of cannabis (compared with prochlorperazine, domperidone, or metoclopramide) with no differences between groups, depending on the type of small group analysis performed [40].

• Marijuana + active
• Drugs versus
• Placebo + active drugs

Two reviews comparing marijuana with placebo marijuana combined with an active drug (opioids and gabapentin).

Both were scored in the middle level. Although one review has shown that cannabis and opioids reduce Thc edibles pain, other pain reviews in MS include only one study [81], which limits the ability to determine the consistency of outcomes.

Cannabis has shown

A variety of effects on non-painful effects, including higher placebo levels than cannabis on specific effects.

One review reported withdrawal due to adverse research-study events and reported that side effects such as nausea, drowsiness, and dizziness were more common with high doses of cannabinoids (data from two included studies).

Cannabis is compared to other cannabis comparisons

Six reviews (8%) compared the different composition of cannabis or doses (Figs. 12 and 13). Almost all were reported as a result of research-based research, with two reviews covering only one RCT. One PTSD review received only observational data and other Cannabis edible regarding the combined anxiety and depression data from a single RCT with cross-sectional study data.

One review in MS reported narrative comparisons that found the benefit of spasticity. However, it was unclear whether the component was placebo or THC alone [56]. Four reviews reported side effects study-by-study, with one review comparing side effects from different doses; In this review, the combined citations of THC and CBD were better tolerated than those of THC alone.

Cannabis against all comparisons

One review included all test comparisons (Fig. 14). The reviews (which included non-users, placebo and ibuprofen) included a range of medical conditions and were rated as low quality. No adverse effects were evaluated in this comparison.

1. Mapping the use of
2. Quality inspections and
3. Frameworks to interpret
4. The strength of evidence

Although 83% of the reviews cover the risk of bias testing in their interpretation of the evidence, only 11 reviews (15%) used a GRADE-like framework to assess important domains without the risk of bias that could inform the strength of the evidence.

Mapping the conclusions or recommendations of the authors

Most reviews (43/72 60%) indicated inability to draw conclusions, whether due to uncertainty, inconsistent findings, lack of evidence (of high quality), or to focus on their conclusion statement on the need for further research. About 15% of reviews (10/72) reported Buy edibles online canada or conclusions that include some uncertainty. One review (1%) provided a statement of the magnitude of the power of evidence, which varied in outcome.