The show revolves around Gujarati homemaker Anupamaa, who is a devoted wife, mother and daughter-in-law. She has a family-oriented and self-sacrificing nature. Time and again, she is humiliated for being a mere housewife and for having an incomplete degree and education.

Anupamaa's husband, Vanraj Shah has been having an affair with his colleague, Kavya Gandhi for the past 8 years. Despite being warned by her best friend, Devika and Kavya's husband, Aniruddh, she refuses to believe it and expresses her faith in Vanraj. On her 25th Wedding Anniversary, when Anupamaa sees Vanraj and Kavya getting intimate, she is left shattered and breaks ties with Vanraj and decides to live her life on her own terms. Anupamaa's younger son, Samar also breaks all ties with Vanraj after learning the same. Rakhi informs the Shahs about the affair leaving them shattered. Soon, Anupamaa's elder son, Paritosh marries Kinjal while Samar and Nandini fall for each other after Samar learns about Nandini's infertility.

Anupamaa takes care of Vanraj's health after he meets with an accident. Vanraj develops a soft corner for Anupama Watch Online. He tries to express his feelings to her, but Anupamaa rebukes him for it. Anupamaa decides to start afresh and tells Vanraj that she wants a divorce. Vanraj fears losing Anupamaa and his family and leaves the house. Anupamaa finds him in a wellness resort in Surat and confronts him.

Anupamaa gets diagnosed  and asks Vanraj to sign the divorce papers. Later, Kavya and Aniruddh gets divorced with Kavya preparing for her wedding with Vanraj. Vanraj goes missing on the wedding day and is confronted by Anupamaa for lacking courage as well as commitment. Kavya and Vanraj get married. After getting successfully treated by an emergency surgery, Hasmukh asks Anupamaa to continue staying with them as she will always remain a part of their family, to which she agrees.

Kavya continuously taunts Anupamaa, trying to humiliate her and failing in her attempts to turn the family against her. Anupamaa Dance Academy gets established with the help of Samar and Nandini and the family rejoices. Anupama Episode advises Vanraj to open a café in her academy but Kavya instigates him against Anupamaa and instead of being grateful for her help, he taunts her.

Anuj Kapadia, a successful business tycoon returns to India from USA. He turns out to be Anupamaa's college batchmate and one-sided lover. Seeing Anuj and Anupamaa spend time together, Vanraj seethes with jealousy. Anuj's team likes Anupamaa's business idea and he offers her a partnership deal in his restaurant. Vanraj fumes and asks her to refuse the offer. Anupamaa signs the contract and joins Anuj as a business partner. Meanwhile, Rohan, Nandini's obsessive former boyfriend returns to win her back and attempts Samar and Anupamaa's murders but gets caught red-handed by Anuj and leaves their lives fearing to be jailed for his father's scams.

Tired of all the taunts and accusations, Anupamaa  decides to move out of the Shah house while Samar leaves with her. Later they start living in a rented house. Kavya makes Vanraj, Dolly and Anupamaa sign the property papers. In his frustration over Anupamaa's repeated character assassination by some family members, Anuj confesses his unrequited love for Anupamaa to the Shahs, unaware that she overheard him. Initially shattered by one-sided love of Anuj, Anupamaa and latter get consoled and convinced by Samar and Gopichandra respectively to continue their relationship as friends.

Anupama desi serial episode day today on air can watch maximum audience of related drama.