This safety assessment includes ammonium and glyceryl and butyl thioglycolates, calcium, ethanolamine, ethyl, isooctyl, isopropyl, magnesium, methyl, potassium, and thioglycolic acid for cosmetic use sodium. Thioglycollate penetrates the skin and distributes to the kidneys, lungs, small intestine, and spleen; excretion is primarily in the urine. Thioglycollate was mildly toxic in an acute oral toxicity study in rats. Thioglycollates can cause mild to severe eye irritation. Thioglycollates may be a skin irritant in animal and in vitro tests and may be a sensitizer. No observable adverse effect level for reproductive and developmental toxicity at 100 mg/kg pe
A day is determined with a mouse. Thioglycollate is not mutagenic and has no evidence of carcinogenicity. Thioglycollates were skin irritants in some clinical trials. Clinically significant adverse reactions to these ingredients used in depilatory agents are uncommon, suggesting that current product formulations are virtually non-irritating under recommended conditions of use. Formulators should take the necessary steps to ensure compliance with current practice. Ethanolamine Thioglycolate Selected as High Priority Cosmetic Ingredient for Cosmetic Ingredient Review (CIR) Review ammonium thioglycolate
A CIR panel of experts completed a safety assessment of ammonium thioglycolate, thioglycolic acid, and glyceryl thioglycolate, concluding that these cosmetic ingredients are safe for use in hair care products up to a concentration of 15.4% (measured at not more than 15.4% thioglycolic acid); however, hairdressers should avoid skin contact and minimize consumer skin contact. 2 Data from earlier safety evaluations of ammonium thioglycolate, glyceryl thioglycolate, and thioglycolic acid have been added to this report with the expectation that these data can be extended to the entire group of thioglycolate salts and esters.